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Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

Microglia can clear amyloid plaques in Alzheimer’s disease. Here, the authors show that specific isoforms of the phospholipid forming APOE lipoproteins activate microglia in pre-clinical mouse models of Alzheimer’s disease.

Nicholas F. Fitz
Kyong Nyon Nam
Radosveta Koldamova
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

J Chapuis
F Hansmannel
J-C Lambert
ResearchOpen Access12 Feb 2013
Molecular Psychiatry

Volume: 18, P: 1225-1234

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Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

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