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Samarium hexaboride is a candidate topological insulator but recent experiments have found behaviour indicative of a metallic Fermi liquid phase. Here the authors show that the conflicting observations can be accommodated by a model where strong interactions drive the formation of exotic neutral quasiparticles.

The superconducting gap of most unconventional superconductors has nodes that support low-energy excitations. Mizukami et al. report that disorder introduced by electron irradiation in BaFe₂(As_1−xP_x)₂induces a sequence of transitions from a nodal to a nodeless gap and then to another gapless state.

Personalized omics profiling can lead to actionable health discoveries and stimulate lifestyle changes.

BepiColombo mission had its first Mercury flyby on 1 October 2021. Here, the authors show plasma measurements taken during this flyby, which reveals that electron injections and subsequent energy-dependent drift is a universal mechanism generating aurorae in the planetary magnetospheres.

Karen Mohlke, Markku Laakso, Michael Boehnke and colleagues report the first application of the Illumina HumanExome Beadchip array, examining association with insulin and glycemic traits in 8,229 nondiabetic Finnish males from the population-based Metabolic Syndrome in Men (METSIM) study. They identify low-frequency coding variants at both known and newly associated loci with insulin processing and secretion.

A study reports that the structural maturation of the matrix domain of the Gag protein of HIV-1 is induced by the proteolytic release and binding of the spacer peptide SP2.

Bis(monoacylglycero)phosphate (BMP) is an important component of late endosomal and lysosomal membranes. In this study, the authors show that both intra- and extralysosomal pathways can contribute to BMP synthesis.

Bleaching threatens corals worldwide as the oceans warm from climate change. Here the authors provide insight into intergenerational acclimatization potential by identifying metabolomic signatures of coral resistance to bleaching at all stages of development, including in the new generation.

Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.

Despite being a charge insulator, YbB₁₂ behaves like a thermal metal. Low-temperature heat-transport measurements of this compound showed its gapless, itinerant and charge-neutral excitations.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

The small GTPases Rnd2 and Rnd3 act downstream of proneural factors to control the migrating behaviour of neurons in the mouse embryonic cerebral cortex. Here, Azzarelli et al. show that Rnd3 binding to the semaphorin receptor PlexinB2 fine-tunes the levels of active RhoA required for cortical neuron migration.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Spin excitations above the ground state of spin ices, geometrically frustrated pyrochlore magnets, are equivalent to pairs of oppositely charged deconfined magnetic monopoles which may propagate through the system. Here, the authors evidence highly itinerant quantum magnetic monopole excitations in Yb₂Ti₂O₇.

High-precision measurements could disclose fundamental dissimilarities between matter and antimatter, which are found imbalanced in the Universe. Here, the authors measure the magnetic moment of the antiproton with six-fold higher accuracy than before, finding it consistent with that of the proton.

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

The innate immune cells undergo metabolic reprogramming upon inflammation. Here, the authors report that both mouse and human microglia display a metabolic reprogramming in the presence of a TLR4 activation, however species-specific enzymes are responsible for this process.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Coherent quantum transition spectroscopy of the spin of a single antiproton is reported, demonstrating Rabi oscillations of the spin and enabling improved measurement of matter/antimatter symmetry using proton and antiproton magnetic moments.

Using biobank data from over 250,000 participants, the authors present a detailed picture of regional and individual variation in the tripartite ancestral structure of modern Japanese populations and demonstrate its impact on elevated body mass index.

Phospholipid scramblase 1 (PLSCR1), a protein induced by IFNγ, acts as a defence factor against SARS-CoV-2 and other coronaviruses by inhibiting the fusion of the virus with host-cell membranes.

Cellular optogenetics applications are limited by difficulties in quantification and blue light toxicity. Here the authors design LOV2-based switches that use resonance energy transfer to overcome these concerns.

A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Frustrated magnetic materials attract significant interest because their properties can become dominated by quantum fluctuations. Here the authors show that excitations in the plateau phase of a quantum magnet can be understood semiclassically even though the ground state involves strong quantum effects.

Genomic analyses of large population-based cohorts uncover the genetic determinants of perivascular space burden, an MRI marker of cerebral small vessel disease, across the lifespan, and reveal potential pathways implicated in the etiology of stroke and dementia.

Silberzan and colleagues demonstrate that local RhoA activity and mechanical forces control the formation of 'migration fingers', cell protrusions involved in the leader-cell-driven collective migration of epithelial cell monolayers.

Ponsioen et al. use a FRET‐based ERK biosensor EKAREN5 in patient‐derived organoids to show that EGFR activity amplifies signal transduction efficiency in KRAS or BRAF mutant MAPK pathways.