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Showing 1–2 of 2 results
Advanced filters: Author: Fabian Giehler Clear advanced filters

  • Epstein-Barr virus causes lymphoma. Here the authors describe a direct complex of the viral oncoprotein LMP1 with the cellular TRAF6 protein as a critical virus-host interface for lymphoma survival and validate this complex as a potential therapeutic target.

    • Fabian Giehler
    • Michael S. Ostertag
    • Arnd Kieser
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • IKK2 is the main mediator of the NF-kappaB pathway. Here, the authors demonstrate that LMP1 sustains the survival of Epstein-Barr virus-transformed human B cells and post-transplant lymphoma through IKK2 that induces JNK signaling through TPL2.

    • Stefanie Voigt
    • Kai R. Sterz
    • Arnd Kieser
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16