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Showing 1–7 of 7 results
Advanced filters: Author: Fabian Lander Clear advanced filters

  • The goal of the 1000 Genomes Project is to provide in-depth information on variation in human genome sequences. In the pilot phase reported here, different strategies for genome-wide sequencing, using high-throughput sequencing platforms, were developed and compared. The resulting data set includes more than 95% of the currently accessible variants found in any individual, and can be used to inform association and functional studies.

    • Richard M. Durbin
    • David Altshuler (Co-Chair)
    • Gil A. McVean
    ResearchOpen Access
    Nature
    Volume: 467, P: 1061-1073

  • Children are less likely to be infected with SARS-CoV-2 and develop less severe disease than adults, which makes estimation of infection rates challenging. Here, the authors conduct seroprevalence surveys of children in Germany, describe changes in prevalence over time, and identify risk factors for infection.

    • Anna-Lisa Sorg
    • Leon Bergfeld
    • Horst Schroten
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • An anthrax-causing agent, Bacillus cereus biovar anthracis, is a persistent and widespread cause of death for a broad range of mammalian hosts in a tropical rainforest, with important implications for the conservation of mammals such as chimpanzees.

    • Constanze Hoffmann
    • Fee Zimmermann
    • Fabian H. Leendertz
    Research
    Nature
    Volume: 548, P: 82-86

  • Metastasis remains difficult to treat owing to the heterogeneity of metastatic cancer cells and the various dynamic steps of the metastatic cascade. This Review discusses the design of nanomedicines for the specific treatment of metastasis.

    • Roger M. Pallares
    • Lorena Consolino
    • Twan Lammers
    Reviews
    Nature Reviews Bioengineering
    Volume: 4, P: 47-66

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559