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Showing 1–2 of 2 results
Advanced filters: Author: Fabian Nikolka Clear advanced filters

  • The ketone body β-hydroxybutyrate can be used as an alternative carbon source by T cells to maintain their function during severe respiratory viral infections, including infection with SARS-CoV-2.

    • Fotios Karagiannis
    • Konrad Peukert
    • Christoph Wilhelm
    Research
    Nature
    Volume: 609, P: 801-807

  • Itaconate is an immunomodulatory macrophage metabolite. Mesaconate, a structurally similar molecule, is shown to be synthesized from itaconate in inflammatory macrophages and shows similar immunomodulatory effects, despite not repressing tricarboxylic acid cycle activity nor inhibiting succinate dehydrogenase activity.

    • Wei He
    • Antonia Henne
    • Karsten Hiller
    Research
    Nature Metabolism
    Volume: 4, P: 524-533