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Showing 1–6 of 6 results
Advanced filters: Author: Fabian den Brave Clear advanced filters
  • An analysis of MitCOM—a comprehensive resource for the identification, organization and interaction of mitochondrial machineries and pathways in yeast—identifies a constitutive pathway for the removal of preproteins.

    • Uwe Schulte
    • Fabian den Brave
    • Thomas Becker
    ResearchOpen Access
    Nature
    Volume: 614, P: 153-159
  • rDNA repeats residing in the nucleolus must be released to the nucleoplasm to allow repair by homologous recombination. Here the authors reveal insights into the molecular mechanism proposing that phosphorylation and SUMOylation of the rDNA-tethering complex facilitate the nucleolar release of damaged repeats to maintain genome integrity.

    • Matías Capella
    • Imke K. Mandemaker
    • Sigurd Braun
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16
  • Impaired tricarboxylic acid cycle and oxidative phosphorylation cause reduced energy content in neurons upon neuroinflammation and contribute to axonal degeneration in multiple sclerosis.

    • Swadha Mishra
    • Fabian den Brave
    • Thomas Becker
    News & Views
    Nature Metabolism
    Volume: 5, P: 1258-1259
  • Cells respond to mitochondrial protein import stress by regenerating clogged import sites and inducing stress responses. Mitochondria are thus tightly integrated into the cellular proteostasis and stress-response network to maintain cell viability.

    • Nikolaus Pfanner
    • Fabian den Brave
    • Thomas Becker
    Reviews
    Nature Cell Biology
    Volume: 27, P: 188-201