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Showing 1–4 of 4 results
Advanced filters: Author: Fabien Delerue Clear advanced filters

  • Conventional PROTACs have limited capacity for misfolded proteins. Here, authors develop a BioPROTAC containing an scFv specifically targeting misfolded SOD1, fused to an E3 ligase, and demonstrate a strategy for reducing misfolded SOD1 accumulation.

    • Christen G. Chisholm
    • Rachael Bartlett
    • Justin J. Yerbury
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • While DNA methylation is thought to play a regulatory role, there are few examples where modification of a single CpG dinucleotide directly affects transcription factor binding. Here the authors show that methylation of a single CGATA element within the c-Kit gene inhibits binding and regulation by erythroid transcription factor GATA-1, both in cells and in mice, suggesting that methylation at this site plays an essential role in erythropoiesis.

    • Lu Yang
    • Zhiliang Chen
    • Merlin Crossley
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Reproducibility is key to all fields of research, and in the case of animal research, this can be hampered by inconsistent reporting of animal genetics. Here the authors propose a reporting framework and guidelines designed to discuss the validation and standardise the reporting of genetic backgrounds and genetic alterations in animal models.

    • Lydia Teboul
    • James Amos-Landgraf
    • Guillaume Pavlovic
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-8