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Showing 1–4 of 4 results
Advanced filters: Author: Fabien Ectors Clear advanced filters

  • Gonadotropes in the pituitary secrete follicle-stimulating hormone and luteinizing hormone to control gonadal function and fertility, but whether they exert actions on extra-gonadal organs is not fully understood. Here the authors report that gonadotropes regulate liver steatosis independent of the ovaries in mice.

    • Sen Qiao
    • Samer Alasmi
    • Ulrich Boehm
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the lung.

    • Barbara Spix
    • Elisabeth S. Butz
    • Christian Grimm
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Growth hormone (GH) is a major modulator of physical growth and metabolism that is under tight regulatory control. Here the authors describe the signaling profile of GPR101, an orphan receptor that enhances GH secretion principally via constitutively activated Gs-PKA and Gq/11-PKC pathways.

    • Dayana Abboud
    • Adrian F. Daly
    • Julien Hanson
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16