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Showing 1–7 of 7 results
Advanced filters: Author: Fabrice Darbellay Clear advanced filters

  • Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also reveal links between Pitx1 expression and genome topology.

    • Olimpia Bompadre
    • Raquel Rouco
    • Guillaume Andrey
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Approximately a quarter of the human genome consists of gene deserts. Here, Abassah-Oppong et al. reveal the biological relevance, embryonic functions and underlying enhancer architecture of a genomic gene desert flanking the Shox2 transcription factor essential for limb, craniofacial and cardiac pacemaker development.

    • Samuel Abassah-Oppong
    • Matteo Zoia
    • Marco Osterwalder
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24

  • Chondrocyte differentiation controls skeleton development and stature. Here, the authors map mouse fetal chondrocyte enhancers, highlighting their role in controlling bone genes and connecting stature to non-coding variants overlapping these enhancers.

    • Fabrice Darbellay
    • Anna Ramisch
    • Guillaume Andrey
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Rajderkar et al. provide a genome-wide compendium of transcriptional enhancers active in human craniofacial development, along with single-cell resources for studies of mammalian craniofacial morphogenesis.

    • Sudha Sunil Rajderkar
    • Kitt Paraiso
    • Axel Visel
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Similar to CTCF, MAZ insulates repressed posterior Hoxa genes from the spreading of anterior active regulatory cues during motoneuron differentiation. This discovery provides new perspectives to understand chromatin organization and insulation.

    • Fabrice Darbellay
    • Raquel Rouco
    • Guillaume Andrey
    News & Views
    Nature Genetics
    Volume: 54, P: 96-97