In this study, the authors show that the monoclonal antibody, FNI9, potently inhibits neuraminidases across H5N1 viruses spanning almost 30 years of evolution, protects mice from lethal challenge, and targets an H5N1-conserved NA epitope predicted to have low mutational escape and high fitness cost.
- Saya Moriyama
- Julia di Iulio
- Matteo Samuele Pizzuto