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Nature Cancer (1)

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Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer

Miller et al. show that blocking ACSS2 remodels acetate metabolism in cancer cells, thereby freeing acetate for tumor-infiltrating lymphocytes, which bolsters their effector function and promotes antitumor immunity in breast cancer.

Katelyn D. Miller
Seamus O’Connor
Zachary T. Schug
Research18 Sept 2023
Nature Cancer

Volume: 4, P: 1491-1507

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Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer

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