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Showing 1–2 of 2 results
Advanced filters: Author: Fabrizio C. Lucchini Clear advanced filters
  • Understanding the regulatory mechanisms governing brown and beige adipose mediated thermogenesis is of interest in order to develop therapeutic strategies to treat obesity. Here, the authors show that adipocyte-expressed apoptosis signal-regulating kinase 1 (ASK1) inhibits browning in response to cold, β3 receptor activation, and LPS.

    • Fabrizio C. Lucchini
    • Stephan Wueest
    • Daniel Konrad
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Hepatic steatosis is a common disease closely associated with metabolic syndrome and insulin resistance. Here Item et al. show that Fas, a member of the TNF receptor superfamily, contributes to mitochondrial dysfunction, steatosis development, and insulin resistance under high fat diet.

    • Flurin Item
    • Stephan Wueest
    • Daniel Konrad
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10