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Showing 1–3 of 3 results
Advanced filters: Author: Fabrizio Giordanetto Clear advanced filters

  • When cytochrome c is released from mitochondria, it interacts with Apaf-1 to activate death-promoting caspases. Now, a gain-of-function mutation affecting cytochrome c with enhanced caspase-stimulatory activity is shown to have no other consequences for human health than a subclinical thrombocytopenia, showing that, in most settings, enhanced cytochrome c activity per se is not sufficient to disturb normal tissue homeostasis.

    • Eric Solary
    • Fabrizio Giordanetto
    • Guido Kroemer
    News & Views
    Nature Genetics
    Volume: 40, P: 379-380

  • Small molecule activators of the energy sensing kinase AMPK are promising candidates as therapies for metabolic disease. Xiao et al. present the crystal structure of AMPK in complex with a small molecule activator, and show that the drug stabilizes interaction between the catalytic and carbohydrate-binding domains.

    • Bing Xiao
    • Matthew J. Sanders
    • Steven J. Gamblin
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-10