The prostate is an immune-competent organ and several stimuli have been identified as possible triggers for dysregulation of the prostatic immune system via molecular pathways involving the development of inflammatory infiltrates. From a pathophysiological standpoint, subsequent tissue damage and chronic tissue healing could result in the development of BPH nodules. In this Review, the authors discuss the immunopathology of BPH and consider its links to prostate cancer and other disorders from an immunological viewpoint.
- Cosimo De Nunzio
- Fabrizio Presicce
- Andrea Tubaro
