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Showing 1–2 of 2 results
Advanced filters: Author: Fadzai V. Makota Clear advanced filters

  • T follicular helper (TFH) cells are important for the generation of effective antibody responses. Yu and colleagues find that TFH cells are exceptionally sensitive to death by ferroptosis and that this process is regulated by the activity of the selenoenzyme GPX4.

    • Yin Yao
    • Zhian Chen
    • Di Yu
    Research
    Nature Immunology
    Volume: 22, P: 1127-1139

  • T follicular helper (TFH) cell numbers are increased after vaccination and fewer of these cells might result in reduced vaccine responses. Here the authors show in mice and humans that leptin promotes TFH differentiation and that low leptin levels can impair TFH response to vaccines and virus protection in mice.

    • Jun Deng
    • Qian Chen
    • Di Yu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15