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Showing 1–4 of 4 results
Advanced filters: Author: Fai Yiu Siu Clear advanced filters
  • The X-ray crystal structure of the human glucagon receptor, a potential drug target for type 2 diabetes, offers a structural basis for molecular recognition by class B G-protein-coupled receptors.

    • Fai Yiu Siu
    • Min He
    • Raymond C. Stevens
    Research
    Nature
    Volume: 499, P: 444-449
  • Designed β-strand peptides stabilize integral membrane proteins for biochemical and structural studies, enabling electron microscopy analysis of the dynamic conformations of the ABC transporter MsbA.

    • Houchao Tao
    • Sung Chang Lee
    • Qinghai Zhang
    Research
    Nature Methods
    Volume: 10, P: 759-761
  • The identification of genes that control economically important traits is an essential step towards crop improvement. Here the authors sequence the genome of the wild soybean and, through a combined genetic and functional approach, identify a new gene affecting salt tolerance in soybean.

    • Xinpeng Qi
    • Man-Wah Li
    • Hon-Ming Lam
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-11
  • The crystal structure of the human smoothened (SMO) receptor is presented in complex with a small-molecule antitumour agent; this represents the first example of a non-class-A, 7-transmembrane (7TM) receptor structure, revealing different conserved motifs common within class frizzled 7TM receptors and an unusually complex arrangement of long extracellular loops stabilized by disulphide bonds.

    • Chong Wang
    • Huixian Wu
    • Raymond C. Stevens
    Research
    Nature
    Volume: 497, P: 338-343