Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: Faizaan Mohammad Clear advanced filters

  • CRISPR editing of all 28 alleles encoding histones H3.1, H3.2 and H3.3 in mouse embryonic stem cells (mESCs) generates pan-H3K27R mutant mESCs, which are transcriptionally similar to PRC2-null mESCs. H3K27 acetylation is dispensable for gene derepression in mESCs and for gene activation in epiblast-like cells.

    • Aditya Sankar
    • Faizaan Mohammad
    • Kristian Helin
    Research
    Nature Genetics
    Volume: 54, P: 754-760

  • Although mechanisms wherein pre-existing H3K27 methylation directs recruitment of PRC2 to support its own maintenance have been proposed, H3K27 methylation patterns in mESCs are not dependent on self-autonomous epigenetic inheritance.

    • Jonas W. Højfeldt
    • Anne Laugesen
    • Kristian Helin
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 225-232

  • Although mutant H3K27M histones inhibit PRC2 in diffuse intrinsic pontine gliomas, these tumors exhibit significant amounts of PRC2 activity. The repression of several genes, including INK4A, by residual EZH2 activity is required for tumor growth, and EZH2 inhibitors therefore represent potential therapies for these patients.

    • Faizaan Mohammad
    • Simon Weissmann
    • Kristian Helin
    Research
    Nature Medicine
    Volume: 23, P: 483-492