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Showing 1–3 of 3 results
Advanced filters: Author: Fangzhi Peng Clear advanced filters

  • Spirocycles are traditionally difficult structures to synthesize due to the congested nature of the central atom. Here the authors show a method to synthesize quaternary carbon spirocycles in one step from 1,3-enynes and pyrazolidine-type heterocycles, both relatively unactivated structures, proceeding via palladium catalysis.

    • Long Li
    • Shan Wang
    • Zhihui Shao
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Enantiodivergent methods, which to access both enantiomers of the same compound, are of importance in drug synthesis. Here, the authors show that by simply changing a NiBu- to a NMe-group in readily available amine organocatalysts, high stereocontrol and broad scope are achieved in eight asymmetric reactions.

    • Jun Dai
    • Zhuang Wang
    • Zhihui Shao
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8

  • Chiral spirocyclic scaffolds have garnered significant attention in drug discovery and chiral ligand development due to their rigid structures and potential bioactive properties. Herein, the authors report a dynamic radical recombination strategy that enables cobalt-hydride-catalyzed ligand-controlled stereodivergent olefin hydroalkylation, delivering a series of spirocyclic compounds bearing 1,3-non-adjacent stereocenters.

    • Zheng Sun
    • Jichao Huang
    • Zhihui Shao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14