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BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma

Metabolic dysregulation in the development of clear cell renal cell carcinoma (ccRCC) remains to be understood. Here the authors identify that a carnitine synthesis enzyme BBOX1, which inhibits TBK1-mTORC1 signaling and glycolysis, is often lost in ccRCC.

Chengheng Liao
Lianxin Hu
Qing Zhang
ResearchOpen Access11 Feb 2025
Nature Communications

Volume: 16, P: 1-18
Sparse and transferable three-dimensional dynamic vascular reconstruction for instantaneous diagnosis

Yinheng Zhu et al. present AutoCAR, an automated algorithm for reconstructing three-dimensional cardiovascular structures from X-ray images. It uses transfer learning and vascular graph optimization to achieve high efficiency and accuracy, with the goal to enable medical procedures and diagnosis in real-world settings.

Yinheng Zhu
Yong Wang
Shaohua Ma
Research21 Apr 2025
Nature Machine Intelligence

Volume: 7, P: 730-742
SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers

Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

Jin Zhou
Austin Hepperla
Qing Zhang
ResearchOpen Access05 Jun 2025
Nature Communications

Volume: 16, P: 1-19
Rapid vessel segmentation and reconstruction of head and neck angiograms using 3D convolutional neural network

Manual postprocessing of computed tomography angiography (CTA) images is extremely labor intensive and error prone. Here, the authors propose an artificial intelligence reconstruction system that can automatically achieve CTA reconstruction in healthcare services.

Fan Fu
Jianyong Wei
Jie Lu
ResearchOpen Access24 Sept 2020
Nature Communications

Volume: 11, P: 1-12
Correction: Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders

Haiyu Li
Yongyao Tang
Yaokai Chen
Amendments and CorrectionsOpen Access12 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-2
Epidemiological Characteristics of Atrial Fibrillation in Southern China: Results from the Guangzhou Heart Study

Hai Deng
Pi Guo
Shulin Wu
ResearchOpen Access13 Dec 2018
Scientific Reports

Volume: 8, P: 1-10
Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders

Haiyu Li
Yongyao Tang
Yaokai Chen
ResearchOpen Access04 Oct 2022
Cell Death & Disease

Volume: 13, P: 1-12
An optimized protocol for stepwise optimization of real-time RT-PCR analysis

Fangzhou Zhao
Nathan A. Maren
Wusheng Liu
ResearchOpen Access01 Aug 2021
Horticulture Research

Volume: 8, P: 1-21

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BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma

Sparse and transferable three-dimensional dynamic vascular reconstruction for instantaneous diagnosis

SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers

Rapid vessel segmentation and reconstruction of head and neck angiograms using 3D convolutional neural network

Correction: Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders

Epidemiological Characteristics of Atrial Fibrillation in Southern China: Results from the Guangzhou Heart Study

Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders

An optimized protocol for stepwise optimization of real-time RT-PCR analysis

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