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Showing 1–4 of 4 results
Advanced filters: Author: Fanyi Mo Clear advanced filters

  • Engineered pyroptotic vesicles formed during tumour cell pyroptosis and engineered as personalized tumour vaccines can activate a robust antitumour immune response for post-surgical tumour recurrence inhibition.

    • Zhaoting Li
    • Yixin Wang
    • Quanyin Hu
    Research
    Nature Nanotechnology
    Volume: 20, P: 1108-1118

  • Activation of ESCRT-mediated cell membrane repair can reduce the extent of tumor cell pyroptosis. Here the authors develop two formulations (an injectable hydrogel and a cell patch) for the sustained release of a Gasdermin-D bacteria-based delivery system and of biodegradable nanoparticles loaded with an ESCRT inhibitor, triggering pyroptosis and antitumor immune responses in preclinical cancer models.

    • Zhaoting Li
    • Fanyi Mo
    • Quanyin Hu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Increased density of tumor associated macrophages has been correlated with tumor recurrence following surgery. Here the authors design an alginate-based hydrogel encapsulating anti-PD-1-conjugated platelets and nanoparticles loaded with the macrophage-depleting CSF-1R inhibitor pexidartinib, showing inhibition of post-surgery tumor recurrence in preclinical models.

    • Zhaoting Li
    • Yingyue Ding
    • Quanyin Hu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

    • Jiaming Li
    • Mengmeng Jiang
    • Guang-Hui Liu
    Reviews
    Nature Aging
    Volume: 5, P: 1669-1685