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Showing 1–2 of 2 results
Advanced filters: Author: Fareheh Firouzi Clear advanced filters
  • Various intrinsic and extrinsic factors influence the balance between cellular renewal and senescence in the ageing heart. In this Review, Gude and colleagues discuss these factors, including environment, lifestyle, genetics and epigenetics, inflammation, and oxidative stress, and how they might be therapeutically targeted.

    • Natalie A. Gude
    • Kathleen M. Broughton
    • Mark A. Sussman
    Reviews
    Nature Reviews Cardiology
    Volume: 15, P: 523-542
  • Broughton et al. report differences between rodent and large mammals with respect to ploidy of the cardiac interstitial cell population. These species-specific differences in ploidy of cardiac interstitial cells suggest potential challenges in extrapolating myocardial preclinical studies from rodent to large mammals.

    • Kathleen M. Broughton
    • Tiffany Khieu
    • Mark A. Sussman
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-14