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Showing 1–10 of 10 results
Advanced filters: Author: Farzad Hamdi Clear advanced filters

  • How do bacteria control formate flow, essential for microbial life? Researchers detected specialized molecular checkpoints that fine-tune small-molecule transport by combining cryo-electron microscopy with in silico, in vitro and in vivo approaches.

    • Christian Tüting
    • Kevin Janson
    • Panagiotis L. Kastritis
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • The cryo-EM structure of the yeast SEA complex suggests that SEACAT functions as a scaffold for binding TORC1 regulators.

    • Lucas Tafur
    • Kerstin Hinterndorfer
    • Robbie Loewith
    ResearchOpen Access
    Nature
    Volume: 611, P: 399-404

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • A variety of artificial cells springs from the functionalization of liposomes with proteins but these models suffer from low durability without repair and replenishment mechanisms. Here, the authors show that synthetic amphiphile membranes undergo SNARE-mediated fusion, and determine bending rigidity and pore edge tension as key parameters for fusion.

    • Lado Otrin
    • Agata Witkowska
    • Tanja Vidaković-Koch
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • This integrative structural biology study elucidates the architecture of the L-A virus at the highest resolution reported to-date. The employed methodology to study yeast cell extracts with minimum perturbation allows exploring protein interactions involved in endogenous virus assembly and function.

    • Lisa Schmidt
    • Christian Tüting
    • Panagiotis L. Kastritis
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-12

  • Multi-scale and integrative structural analyses provide insight into metabolic regulation by the higher-order architecture of the Chaetomium thermophilum oxoglutarate dehydrogenase complex (OGDHc) metabolon.

    • Ioannis Skalidis
    • Fotis L. Kyrilis
    • Panagiotis L. Kastritis
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-15