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Showing 1–3 of 3 results
Advanced filters: Author: Fatemeh Alikarami Clear advanced filters

  • GPC2 and GD2 have been described as immunotherapeutic targets in neuroblastoma. Here the authors engineer T cells to simultaneously express a GPC2-directed CAR and a bispecific innate immune cell engager targeting GD2 and CD16a, showing antitumor activity in neuroblastoma preclinical models.

    • Guillem Pascual-Pasto
    • Brendan McIntyre
    • Kristopher R. Bosse
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • The imminent release of tissue atlases combining multichannel microscopy with single-cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards to guide data deposition, curation and release. We describe a Minimum Information about Highly Multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and for other microscopy data to highly multiplexed tissue images and traditional histology.

    • Denis Schapiro
    • Clarence Yapp
    • Peter K. Sorger
    Comments & Opinion
    Nature Methods
    Volume: 19, P: 262-267