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Showing 1–4 of 4 results
Advanced filters: Author: Federico Tortelli Clear advanced filters

  • A chemical screen identified BET bromodomain inhibitors as promoters of keratinocyte regenerative function and skin wound healing. Specifically, low-dose transient treatment with BET inhibitors imposes an activated, migratory state in keratinocytes.

    • Gabi Schutzius
    • Christian Kolter
    • Susan Kirkland
    Research
    Nature Chemical Biology
    Volume: 17, P: 280-290

  • Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

    • Russell L. McLaughlin
    • Dick Schijven
    • Michael C. O’Donovan
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Ammar Al-Chalabi, Jan Veldink and colleagues perform a genome-wide association study for amyotrophic lateral sclerosis (ALS) in 15,156 cases and 26,242 controls. They identify three new genome-wide-significant variants and establish ALS as a complex trait with a polygenic architecture, but with a distinct and important role for low-frequency variants.

    • Wouter van Rheenen
    • Aleksey Shatunov
    • Jan H Veldink
    Research
    Nature Genetics
    Volume: 48, P: 1043-1048