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Showing 1–4 of 4 results
Advanced filters: Author: Feiya Ou Clear advanced filters

  • Some enhancers can limit their activities to specific spatial–temporal domains by enhancer suboptimization. Ou et al. find that classical dendritic cell (cDC) development depends on Irf8 suboptimization, which prevents unwanted IRF8 autoactivation in developing cDC2s while maximizing IRF8 expression in developed cDC1s.

    • Feiya Ou
    • Tian-Tian Liu
    • Kenneth M. Murphy
    Research
    Nature Immunology
    Volume: 25, P: 2043-2056

  • Bladder cancer is one of the most common and highly vascularized cancers. Here the authors perform a whole-genome analysis in urothelial bladder carcinomas and identify recurrent genetic alterations in a set of angiogenesis genes, facilitating the understanding of molecular mechanisms underlying pathological angiogenesis in this type of cancer.

    • Song Wu
    • Tong Ou
    • Zhiming Cai
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • The transcription factor NFIL3 acts antagonistically to C/EBP proteins by binding the Zeb2 enhancer to prevent Zeb2 expression and the development of the conventional type 2 dendritic cell lineage.

    • Tian-Tian Liu
    • Sunkyung Kim
    • Kenneth M. Murphy
    Research
    Nature
    Volume: 607, P: 142-148

  • CD40 is typically understood as a costimulatory molecule. Here, the authors show CD4+ T cell-induced CD40 signaling in conventional type 1 dendritic cells results in complicated gene expression that can enhance CD8+ T cell priming by various underappreciated and independent mechanisms.

    • Renee Wu
    • Ray A. Ohara
    • Kenneth M. Murphy
    Research
    Nature Immunology
    Volume: 23, P: 1536-1550