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Showing 1–7 of 7 results
Advanced filters: Author: Felice-Alessio Bava Clear advanced filters

  • Despite playing a central role the treatment of B-cell precursor acute lymphoblastic leukaemia (BCP-ALL), resistance to glucocorticoids remains a major obstacle. Here, the authors identify activation of PI3K/mTOR and CREB pathways as a driver of GC-resistance in BCP-ALL and restore sensitivity using the multi kinase inhibitor, dasatinib.

    • Jolanda Sarno
    • Pablo Domizi
    • Kara L. Davis
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • CPEB1 is known to regulate cytoplasmic polyadenylation, and is now shown to have a second function in the nucleus; it associates with the cleavage and polyadenylation machinery, thereby promoting usage of an upstream poly(A) signal in many messenger RNAs, and affecting alternative splicing.

    • Felice-Alessio Bava
    • Carolina Eliscovich
    • Raúl Méndez
    Research
    Nature
    Volume: 495, P: 121-125

  • Recent studies have revealed how poly(A) tail length and the selection of alternative polyadenylation sites contribute to translational control. This Review discusses how mechanisms of alternative polyadenylation, deadenylation and cytoplasmic polyadenylation are coordinated to modulate gene expression in inflammation, learning and memory acquisition, and early development.

    • Laure Weill
    • Eulàlia Belloc
    • Raúl Méndez
    Reviews
    Nature Structural & Molecular Biology
    Volume: 19, P: 577-585

  • Maeve O’Huallachain et al. report a method that enables simultaneous, ultra-high throughput single-cell barcoding for targeted single-cell protein and RNA analysis. They show the utility of their method in analyses of mRNA and protein expression in human and mouse cells.

    • Maeve O’Huallachain
    • Felice-Alessio Bava
    • Garry P. Nolan
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-19