Dysfunctionality of T lymphocytes has been implicated in cancer and infection, however, the role of CD4 T cells remains understudied. The authors here generate a TCR transgenic mouse model for the study of dysfunctional CD4 T cells directed against a tumor-specific antigen, which can be reinvigorated by checkpoint blockade and vaccination.
- Felicia S. Spitzer
- Marcel G. M. Camps
- Ferry Ossendorp
