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Showing 1–2 of 2 results
Advanced filters: Author: Felipe E. Ciamponi Clear advanced filters

  • Type I PRMT inhibition elicits potent antitumor activity associated with increased interferon response and intron-retained dsRNA accumulation, suggesting its potential combination with immune checkpoint inhibitors for cancer treatment.

    • Qin Wu
    • David Y. Nie
    • Cheryl H. Arrowsmith
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 18, P: 821-830

  • The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in vivo, suggesting that PRMT5 inhibition may be a useful therapeutic strategy

    • Patty Sachamitr
    • Jolene C. Ho
    • Peter B. Dirks
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17