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Showing 1–5 of 5 results
Advanced filters: Author: Felix C. Keber Clear advanced filters

  • Keber et al. use filtration chromatography and quantitative proteomics of Xenopus egg extracts and show that at least 18% of cytoplasmic proteins are organized in small ~100-nm biomolecular condensates.

    • Felix C. Keber
    • Thao Nguyen
    • Martin Wühr
    Research
    Nature Cell Biology
    Volume: 26, P: 346-352

  • The actomyosin cytoskeleton consists of a contractile array but how it becomes organized is not clear. Here the authors reconstitute a controllable contractile system to show that force balances at boundaries determine contraction dynamics, and spatial anisotropy leads to self-organization or aligned contractile fibres.

    • Matthias Schuppler
    • Felix C. Keber
    • Andreas R. Bausch
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Here the authors address how embryos control the timing of specific gene activation in early frog development. They find transcription factors for early gene activation are maternally loaded and remain at constant levels, and rather that order of activation is based on their sequential entry into the nucleus based largely on their respective affinity to importins.

    • Thao Nguyen
    • Eli J. Costa
    • Martin Wühr
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Sinonasal tumour diagnosis can be complicated by the heterogeneity of disease and classification systems. Here, the authors use machine learning to classify sinonasal undifferentiated carcinomas into 4 molecular classe with differences in differentiation state and clinical outcome.

    • Philipp Jurmeister
    • Stefanie Glöß
    • David Capper
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Cell membrane protrusions and invaginations are both driven by actin assembly but the mechanism leading to different membrane shapes is unknown. Using a minimal system and modelling the authors reconstitute the deformation modes and identify capping protein as a regulator of both deformation types.

    • Katharina Dürre
    • Felix C. Keber
    • Andreas R. Bausch
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11