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Showing 1–6 of 6 results
Advanced filters: Author: Felix Gunawan Clear advanced filters

  • Gunawan et al. propose an Extensible Immunofluorescence (ExIF) strategy that integrates distinct 4-plex image panels from routine fluorescence microscopy into multiplexed datasets enabling quantitative interrogation of complex, multimolecular single-cell processes.

    • Ihuan Gunawan
    • Felix V. Kohane
    • John G. Lock
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The endocardium lines the interior of the heart chambers and has been debated as a source of hematopoietic lineages. Here they show that the endocardium may act as a source of, and resident tissue for, hematopoietic stem and progenitor cells in zebrafish, providing evidence for diversity in origins and residences of hematopoietic cells.

    • Dorothee Bornhorst
    • Amulya V. Hejjaji
    • Felix Gunawan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Albu et al. show that muscle cells in the cardiac atrium construct structures through heterogeneous cell behaviors that are different, at the cellular and molecular levels, from those involved during ventricular chamber maturation.

    • Marga Albu
    • Eileen Affolter
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Proper heart development and synchronous cardiomyocyte contraction rely on tissue integrity. Here the authors show that the ubiquitin-proteasome system and the E3 ubiquitin ligase ASB2 in particular are crucial for cardiomyocyte maturation and tissue integrity through the degradation of the TCF3 transcription factor.

    • Ryuichi Fukuda
    • Felix Gunawan
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Abnormal alveolar development and homeostasis are common features of pulmonary disease. Here the authors show that Myh10 expression is reduced in emphysema patients, and that Myh10 loss of function impairs alveolar formation and lung morphogenesis via upregulation of matrix metalloproteinase activity and altered matrix remodeling.

    • Hyun-Taek Kim
    • Wenguang Yin
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Tubulogenesis is required for the formation of many internal structures including the trachea. Here, the authors show that the potassium channel KCNJ13 regulates tracheal tube formation, with shorter tracheas forming in mutant mice due in part to changes in actin organization in tracheal smooth muscle cells.

    • Wenguang Yin
    • Hyun-Taek Kim
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13