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Showing 1–6 of 6 results
Advanced filters: Author: Felix Kümmerer Clear advanced filters

  • Asymmetric phospholipid distribution in cell membranes is vital for cellular function. Here, authors reveal how ATP8B1, a P4-ATPase, can transport different lipids, including phosphatidylinositol.

    • Thibaud Dieudonné
    • Felix Kümmerer
    • Poul Nissen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Constriction of the selectivity filter is assumed to be a hallmark of C-type inactivation in K+ channels. Using different high-resolution methods, this study shows a distinct C-type inactivation mechanism in a KcsA mutant that emulates Kv-channels.

    • Ahmed Rohaim
    • Bram J. A. Vermeulen
    • Markus Weingarth
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dynamics which perturb the selectivity filter.

    • Shehrazade Jekhmane
    • João Medeiros-Silva
    • Markus Weingarth
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Deep learning has resulted in impressive achievements, but under what circumstances does it fail, and why? The authors propose that its failures are a consequence of shortcut learning, a common characteristic across biological and artificial systems in which strategies that appear to have solved a problem fail unexpectedly under different circumstances.

    • Robert Geirhos
    • Jörn-Henrik Jacobsen
    • Felix A. Wichmann
    Reviews
    Nature Machine Intelligence
    Volume: 2, P: 665-673

  • This Perspective describes the development and capabilities of SciPy 1.0, an open source scientific computing library for the Python programming language.

    • Pauli Virtanen
    • Ralf Gommers
    • Yoshiki Vázquez-Baeza
    ReviewsOpen Access
    Nature Methods
    Volume: 17, P: 261-272