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Showing 1–4 of 4 results
Advanced filters: Author: Felix M. Kühner Clear advanced filters

  • By probing the essentiality of diverse genes encoding mRNA translation factors in different human cell types using CRISPR interference screens, Rodschinka et al. discover that human stem cells critically depend on proteins rescuing stalled or collided ribosomes.

    • Geraldine Rodschinka
    • Sergio Forcelloni
    • Danny D. Nedialkova
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1932-1946

  • The late-stage functionalization of unactivated carbon–hydrogen bonds is a difficult but important task, which has been met with promising but limited success through synthetic organic chemistry. Here the authors use machine learning to engineer WelO5* halogenase variants, which led to regioselective chlorination of inert C–H bonds on a representative polyketide that is a non-natural substrate for the enzyme.

    • Johannes Büchler
    • Sumire Honda Malca
    • Rebecca Buller
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • New mechanistic insights into nanoparticle–plant interactions show that specifically designed silica nanoparticles have the potential to serve as an inexpensive, highly efficient, safe and tracelessly degradable alternative for pesticides.

    • Mohamed El-Shetehy
    • Aboubakr Moradi
    • Fabienne Schwab
    Research
    Nature Nanotechnology
    Volume: 16, P: 344-353

  • Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

    • T. Sunn Pedersen
    • M. Otte
    • Sandor Zoletnik
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10