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Showing 1–4 of 4 results
Advanced filters: Author: Felix Sippel Clear advanced filters

  • Marine Proteobacteria use the β-hydroxyaspartate cycle to assimilate glycolate, which is secreted by algae on a petagram scale, providing evidence of a previously undescribed trophic interaction between autotrophic phytoplankton and heterotrophic bacterioplankton.

    • Lennart Schada von Borzyskowski
    • Francesca Severi
    • Tobias J. Erb
    Research
    Nature
    Volume: 575, P: 500-504

  • So far only a few compounds have been reported as splicing modulators. Here, the authors combine high-throughput screening, chemical synthesis, NMR, X-ray crystallography with functional studies and develop phenothiazines as inhibitors for the U2AF Homology Motif (UHM) domains of proteins that regulate splicing and show that they inhibit early spliceosome assembly on pre-mRNA substrates in vitro.

    • Pravin Kumar Ankush Jagtap
    • Tomáš Kubelka
    • Michael Sattler
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Inhibitors of FKBP51 with antidepressive activity are selective over the related FKBP52 and bind FKBP51 by an induced-fit mechanism that causes a conformational change. The analogous conformational change in FKBP52 generates a strained conformation.

    • Steffen Gaali
    • Alexander Kirschner
    • Felix Hausch
    Research
    Nature Chemical Biology
    Volume: 11, P: 33-37