Amide-bearing organic compounds are important building blocks in organic synthesis, however, the ambident reactivities of the nitrogen and oxygen atoms in the amide moiety requires catalysts and reagents that are able to control the reaction selectivity. Here, hypervalent iodine reagents are shown to mediate the intramolecular cycloisomerization of O-alkenylbenzamides to selectively generate isoquinolinone and iminoisocoumarin derivatives.
- Jiaxin He
- Feng-Huan Du
- Yunfei Du
