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Showing 1–4 of 4 results
Advanced filters: Author: Fengan Li Clear advanced filters
  • Characterization of a family of Stigonematales (Stig) cyclases that catalyze stereoselective intramolecular C–C bond formation reveals the enzymatic origins of the complex stereochemical patterns in hapalindole and fischerindole alkaloids.

    • Shasha Li
    • Andrew N Lowell
    • David H Sherman
    Research
    Nature Chemical Biology
    Volume: 13, P: 467-469
  • Failure of conventional clinical therapies such as tumor resection and chemotherapy are mainly due to the ineffective control of tumor metastasis. Here, the authors show that a systemic metastasis-targeted nanotherapeutic may offer a powerful adjunct therapy for suppressing tumor metastasis.

    • Minjun Xu
    • Kaili Hu
    • Jun Chen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17
  • The structure of a Stig cyclase, HpiC1, reveals how it catalyzes Cope rearrangement and 6-exo-trig cyclization, including how it controls the position of electrophilic aromatic substation that distinguishes hapalindole from fischerindole alkaloids.

    • Sean A. Newmister
    • Shasha Li
    • David H. Sherman
    Research
    Nature Chemical Biology
    Volume: 14, P: 345-351
  • A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

    • Marnix H Medema
    • Renzo Kottmann
    • Frank Oliver Glöckner
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 11, P: 625-631