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Showing 1–6 of 6 results
Advanced filters: Author: Fengan Yu Clear advanced filters

  • Characterization of a family of Stigonematales (Stig) cyclases that catalyze stereoselective intramolecular C–C bond formation reveals the enzymatic origins of the complex stereochemical patterns in hapalindole and fischerindole alkaloids.

    • Shasha Li
    • Andrew N Lowell
    • David H Sherman
    Research
    Nature Chemical Biology
    Volume: 13, P: 467-469

  • The complete biosynthesis of the fungal indole alkaloid malbrancheamide, which culminates in an intramolecular [4+2] hetero-Diels–Alder cyclization to produce the bicyclo[2.2.2]diazaoctane scaffold, has now been discovered. Chemical synthesis and protein structural analysis were used to provide mechanistic insight into this enzyme-dependent diastereo- and enantioselective cycloaddition.

    • Qingyun Dan
    • Sean A. Newmister
    • Robert M. Williams
    Research
    Nature Chemistry
    Volume: 11, P: 972-980

  • Pathogenic microbes can often attach to surfaces and form biofilms that display increased antibiotic resistance. Here, the authors characterize the biosynthesis of a new class of natural products, the cahuitamycins, that inhibit formation of biofilms by the pathogenic bacterium Acinetobacter baumannii.

    • Sung Ryeol Park
    • Ashootosh Tripathi
    • David H. Sherman
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Failure of conventional clinical therapies such as tumor resection and chemotherapy are mainly due to the ineffective control of tumor metastasis. Here, the authors show that a systemic metastasis-targeted nanotherapeutic may offer a powerful adjunct therapy for suppressing tumor metastasis.

    • Minjun Xu
    • Kaili Hu
    • Jun Chen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • The structure of a Stig cyclase, HpiC1, reveals how it catalyzes Cope rearrangement and 6-exo-trig cyclization, including how it controls the position of electrophilic aromatic substation that distinguishes hapalindole from fischerindole alkaloids.

    • Sean A. Newmister
    • Shasha Li
    • David H. Sherman
    Research
    Nature Chemical Biology
    Volume: 14, P: 345-351

  • A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

    • Marnix H Medema
    • Renzo Kottmann
    • Frank Oliver Glöckner
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 11, P: 625-631