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Showing 1–4 of 4 results
Advanced filters: Author: Fengting Bai Clear advanced filters

  • DNA polymerase ζ (Pol ζ) maintains continuity but impairs accuracy during DNA replication. Here, the authors report a mechanism by which human cells precisely control the essential, yet mutagenic, activity of Pol ζ to ensure both continuation and fidelity during DNA replication challenges.

    • Chun Li
    • Shuchen Fan
    • Xialu Li
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • In this work, a photodynamic therapy system based on conjugated polymers (CPs) is developed to inhibit the infection of RNA viruses. Three cationic CPs with different backbone structures fluorene-co-phenylene (PFP), thiophene (PMNT), and phenylene vinylene (PPV) exhibit different photoinactivation effects. PPV and PMNT cause effective inactivation of viruses under light irradiation, while SARS-CoV-2 pseudotyped viruses keep infectious after treated by PFP, which is determined by the interactions between CPs with the proteins and gene of viruses. This work preliminarily reveals the effect of CP-virus interactions on their photoinactivation activity and would be beneficial to develop high-efficient antiviral PDT agents.

    • Ruilian Qi
    • Fengting Lv
    • Shu Wang
    ResearchOpen Access
    NPG Asia Materials
    Volume: 15, P: 1-9