The lateral hypothalamic area is the 'feeding centre' in the brain. During fasting, the neuropeptides orexin and melanin-concentrating hormone (MCH) are released in this area and stimulate food intake. The expression of orexin and MCH is now shown to be regulated by the transcription factor Foxa2, a downstream target of insulin signalling. The results show that Foxa2 can act as a metabolic sensor to integrate metabolic signals, adaptive behaviour and physiological responses.
- Jose P. Silva
- Ferdinand von Meyenn
- Markus Stoffel
