Homeostatic modulators (HMs) are powerful modern therapeutics for human diseases including neuropsychiatric diseases, mental disorders, and drug addiction; however, their discovery is often unpredictable and limited to membrane protein receptors and ion channels. Here, the authors analyze a spectrum of novel HMs for Cdc42, a cytoplasmic small GTPase in the Ras superfamily, with striking biological functionalities and potential therapeutic applications.
- Satyaveni Malasala
- Fereshteh Azimian
- Qun Lu
