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Performance of plasma biomarkers for diagnosis and prediction of dementia in a Brazilian cohort

Plasma biomarkers of Alzheimer’s disease and dementia are remarkable tools but still lack validation in Low and Middle-Income Countries. In this longitudinal study, authors report on the plasma biomarker profile of a Brazilian dementia cohort.

Luis E. Santos
Paulo Mattos
Fernanda G. De Felice
ResearchOpen Access25 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

Expression of the exercise-induced myokine irisin (FNDC5) is lower in patients with AD. Whereas knockdown of FNDC5/irisin is sufficient to induce learning and memory deficits, restoration of its expression can ameliorate these phenotypes in rodent models.

Mychael V. Lourenco
Rudimar L. Frozza
Fernanda G. De Felice
Research07 Jan 2019
Nature Medicine

Volume: 25, P: 165-175
Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

Here, using ex-vivo human adult cortical tissue and a mouse model, the authors investigate the functional consequences of Zika virus (ZIKV) infection in the adult brain, and show that ZIKV causes synapse damage and altered brain function that impacts cognition via activation of innate and inflammatory factors.

Claudia P. Figueiredo
Fernanda G. Q. Barros-Aragão
Sergio T. Ferreira
ResearchOpen Access05 Sept 2019
Nature Communications

Volume: 10, P: 1-16
Impaired insulin signalling and allostatic load in Alzheimer disease

Impaired insulin signalling is now established as a key component of Alzheimer disease (AD) pathology. In this review, De Felice and colleagues discuss the contribution of impaired insulin signalling and allostatic load in AD and highlight the potential of social and lifestyle interventions to preserve brain health and ward off AD.

Fernanda G. De Felice
Rafaella A. Gonçalves
Sergio T. Ferreira
Reviews28 Feb 2022
Nature Reviews Neuroscience

Volume: 23, P: 215-230
Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts

Benedetta Bigio
Ricardo A. S. Lima-Filho
Carla Nasca
Research07 Jan 2025
Molecular Psychiatry

Volume: 30, P: 2573-2583
Podocyte extracellular vesicles and immune mediators as urinary biomarkers in active lupus nephritis

Lilian Alves
Ana Patrícia Lemos
Andrea Alice Silva
ResearchOpen Access05 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice

Paula S. Frost
Fernanda Barros-Aragão
Julia R. Clarke
ResearchOpen Access11 Apr 2019
Cell Death & Disease

Volume: 10, P: 1-13
Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease

Natalia M. Lyra e Silva
Rafaella A. Gonçalves
Fernanda G. De Felice
ResearchOpen Access28 Apr 2021
Translational Psychiatry

Volume: 11, P: 1-15
Defective regulation of the eIF2-eIF2B translational axis underlies depressive-like behavior in mice and correlates with major depressive disorder in humans

Alinny R. Isaac
Mariana G. Chauvet
Mychael V. Lourenco
ResearchOpen Access01 Oct 2024
Translational Psychiatry

Volume: 14, P: 1-8
Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice

A study involving several research models suggests that the function and synaptic localization of proteasomes, intracellular machineries involved in protein degradation, are impaired in the brains affected by Alzheimer’s disease.

Felipe C. Ribeiro
Danielle Cozachenco
Sergio T. Ferreira
ResearchOpen Access07 Nov 2023
Communications Biology

Volume: 6, P: 1-12
Alzheimer’s disease biomarkers and their current use in clinical research and practice

Tai R. Hunter
Luis E. Santos
Fernanda G. De Felice
Reviews04 Sept 2024
Molecular Psychiatry

Volume: 30, P: 272-284
Melatonin: A potential nighttime guardian against Alzheimer’s

Zefan Zhang
Pei Xue
Christian Benedict
ReviewsOpen Access11 Aug 2024
Molecular Psychiatry

Volume: 30, P: 237-250
Hsa-microRNA-1249-3p/Homeobox A13 axis modulates the expression of β-catenin gene in human epithelial cells

Chiara Mazziotta
Maria Rosa Iaquinta
John Charles Rotondo
ResearchOpen Access18 Dec 2023
Scientific Reports

Volume: 13, P: 1-12

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