Vinyl carbocations have a long history in chemistry, but they have received less attention compared to the more common sp2-hybridized trivalent carbocations and synthetic applications of these intermediates are still limited. Herein, the authors report an unexpected formal reductive Friedel-Crafts reaction, enabled by HFIP solvent and a hydride source, that transforms alkynol derivatives via a vinyl cation cyclization into bicyclo[3.3.1]nonane derivatives.
- Olaya García-Pedrero
- Pilar Pardo
- Félix Rodríguez
