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GABA_A receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl⁻-sensitive WNK1 kinase

GABAergic transmission regulates the K⁺-Cl⁻ co-transporter KCC2. Here the authors demonstrate that inhibitory transmission, via GABA_A receptor and WNK signaling, regulates KCC2 expression in the membrane of hippocampal neurons.

Martin Heubl
Jinwei Zhang
Sabine Lévi
ResearchOpen Access24 Nov 2017
Nature Communications

Volume: 8, P: 1-17

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GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase

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GABA_A receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl⁻-sensitive WNK1 kinase