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Showing 1–2 of 2 results
Advanced filters: Author: Fidéline Bonnet-Serrano Clear advanced filters

  • Adrenocortical carcinomas (ACC) are aggressive and often resistant to therapy. Here, the authors provide a single-nucleus transcriptomic atlas of ACCs and normal adrenal glands, finding ecotypes in steroid and microenvironment cells that are associated with clinical outcomes.

    • Anne Jouinot
    • Yoann Martin
    • Guillaume Assié
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • In a new study, an ambulatory microdialysis system combined with ultrasensitive liquid chromatography-tandem mass spectrometry enabled the building of a 24-h high-resolution profile of adrenal steroids in the tissue by sampling interstitial fluid in 214 healthy volunteers. Daily and ultradian variations of eight free steroids, including cortisol and aldosterone, have been demonstrated, which opens new diagnostic perspectives for endocrine diseases.

    • Fidéline Bonnet-Serrano
    • Jérôme Bertherat
    News & Views
    Nature Reviews Endocrinology
    Volume: 19, P: 624-625