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Showing 1–10 of 10 results
Advanced filters: Author: Fidel Alfaro-Almagro Clear advanced filters

  • The potential association between neurodegenerative disease risk and gout is not fully understood. Here the authors showed that gout is causally related to several measures of brain structure which may explain their higher vulnerability to dementia.

    • Anya Topiwala
    • Kulveer Mankia
    • Thomas E. Nichols
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • After infection with SARS-CoV-2, individuals show a greater reduction in grey matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus; greater changes in markers of tissue damage in regions that are functionally connected to the primary olfactory cortex; and a greater reduction in global brain size.

    • Gwenaëlle Douaud
    • Soojin Lee
    • Stephen M. Smith
    ResearchOpen Access
    Nature
    Volume: 604, P: 697-707

  • Genome-wide association studies of brain imaging data from 8,428 individuals in UK Biobank show that many of the 3,144 traits studied are heritable, and genes associated with individual phenotypes are identified.

    • Lloyd T. Elliott
    • Kevin Sharp
    • Stephen M. Smith
    ResearchOpen Access
    Nature
    Volume: 562, P: 210-216

  • The UK Biobank combines detailed phenotyping and genotyping with tracking of long-term health outcomes in a large cohort. This study describes the recently launched brain-imaging component that will ultimately scan 100,000 individuals. Results from the first 5,000 subjects are reported, including thousands of associations, population modes and hypothesis-driven results.

    • Karla L Miller
    • Fidel Alfaro-Almagro
    • Stephen M Smith
    Research
    Nature Neuroscience
    Volume: 19, P: 1523-1536

  • Between 2014 and 2023, 100,000 UK Biobank participants are undergoing brain, heart and abdominal MRI, as well as DXA and carotid ultrasound scans. In this review, authors provide a detailed overview of the rationale for the collection of these imaging data, the procedures of data collection and management, and the future directions of the UK biobank imaging enhancement.

    • Thomas J. Littlejohns
    • Jo Holliday
    • Naomi E. Allen
    ReviewsOpen Access
    Nature Communications
    Volume: 11, P: 1-12