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Showing 1–8 of 8 results
Advanced filters: Author: Fides Zenk Clear advanced filters

  • Here, the authors demonstrate Phospho-seq, a single-cell multiomics method capable of quantifying chromatin accessibility alongside intracellular proteins, including post-translationally modified proteins. Then, they apply Phospho-seq to organoid models of neurodevelopment.

    • John D. Blair
    • Austin Hartman
    • Rahul Satija
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • The mechanisms underlying human cell diversity are unclear. Here the authors provide a single-cell epigenome map of human neural organoid development and dissect how epigenetic changes control cell fate specification from pluripotency to distinct cerebral and retina neural types.

    • Fides Zenk
    • Jonas Simon Fleck
    • Barbara Treutlein
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 1376-1386

  • How heterochromatin is established de novo in early embryos is unknown. A study now shows that the sequential recruitment of the key regulator JARID2 recruits PRC2.2 to H2AK119ub and ensures proper H3K27me2/3 deposition. This prevents premature enhancer activation, which is crucial for gene regulation and lineage specification.

    • Fides Zenk
    News & Views
    Nature Cell Biology
    Volume: 27, P: 5-6

  • Germ layer specification during zygotic genome activation is regulated by chromatin state. Here, the authors use single-cell multiome profiling in Drosophila to show that H3K27me3 and H3K27ac at cis-regulatory elements control cell type-specific gene expression and developmental progression.

    • Francesco Cardamone
    • Annamaria Piva
    • Nicola Iovino
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • A multi-omic atlas of brain organoid development facilitates the inference of an underlying gene regulatory network using the newly developed Pando framework and shows—in conjunction with perturbation experiments—that GLI3 controls forebrain fate establishment through interaction with HES4/5 regulomes.

    • Jonas Simon Fleck
    • Sophie Martina Johanna Jansen
    • Barbara Treutlein
    ResearchOpen Access
    Nature
    Volume: 621, P: 365-372

  • During embryogenesis, the genome becomes transcriptionally active in a process known as zygotic genome activation (ZGA); how ZGA is initiated is still an open question. Here the authors show histone variant H2A.Z deposition precedes RNA polymerase II binding on chromatin, before ZGA. H2A.Z loss causes transcriptional downregulation of ZGA genes and leads to changes in the 3D genome organization.

    • Dafne Ibarra-Morales
    • Michael Rauer
    • Nicola Iovino
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14