Characterizing mice lacking Inositol Polyphosphate-4-Phosphatase Type II B (INPP4B), Zhang et al. discovered that SREBP1 signaling is activated in livers of Inpp4b−/− males leading to development of NAFLD and insulin resistance. When fed high fat diet, Inpp4b−/− males develop type II diabetes, inflammation of adipose tissue, and prostate neoplasia. These findings provide insights into INPP4B protective role from metabolic syndrome.
- Manqi Zhang
- Yasemin Ceyhan
- Irina U. Agoulnik
