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Showing 1–7 of 7 results
Advanced filters: Author: Filip Van den Bosch Clear advanced filters

  • Why does chronic inflammation manifest not only in the joints but also in the gut in a substantial proportion of patients with SpA? Insights into the genetic and environmental factors that link inflammatory bowel disease and SpA are provided in this Review. Furthermore, the authors present a transition model, describing a phase in the disease process during which acute inflammation is transformed into chronic pathology, and suggest that it might present the opportunity for effective therapeutic intervention.

    • Liesbet Van Praet
    • Peggy Jacques
    • Dirk Elewaut
    Reviews
    Nature Reviews Rheumatology
    Volume: 8, P: 288-295

  • The emphasis placed on HLA-B27 positivity in classification criteria for axial spondyloarthritis has generated some concern over potential misclassification of patients with chronic back pain. The results of a recent study suggest that these worries could have some foundation, at least in regions with high HLA-B27 prevalence.

    • Filip Van den Bosch
    • Dirk Elewaut
    News & Views
    Nature Reviews Rheumatology
    Volume: 8, P: 699-700

  • In this Consensus Statement, a Group for Research and Assessment of Psoriasis and Psoriatic Arthritis task force presents consensus definitions for two distinct states, complex-to-manage PsA and treatment-refractory PsA, with the aim of standardizing terminology, improving patient stratification and guiding clinical decision-making and future research.

    • Fabian Proft
    • Andre L. Ribeiro
    • Philip Mease
    Reviews
    Nature Reviews Rheumatology
    Volume: 22, P: 132-144

  • The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.

    • Koen Venken
    • Peggy Jacques
    • Dirk Elewaut
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Here, the authors propose that more stringent MRI definitions for inflammatory and structural lesions in the sacroiliac joints should be used in randomized controlled trials in non-radiographic axial spondyloarthritis. They argue that such an approach might enhance diagnostic accuracy and thereby increase discrimination between therapies.

    • Walter P. Maksymowych
    • Robert G. W. Lambert
    • Mikkel Østergaard
    Reviews
    Nature Reviews Rheumatology
    Volume: 18, P: 481-489