The ubiquitin ligase RACO-1 is found to be a co-factor for the AP-1 transcription factor c-Jun, and its depletion reduces AP-1 target gene expression, proliferation and tumour formation. RACO-1 is stabilised by growth factors through the MEK/ERK pathway, which promotes K63 linked ubiquitylation, opposing the K48-linked proteolytic auto-ubiquitylation of RACO-1.
- Clare C. Davies
- Atanu Chakraborty
- Axel Behrens
