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Showing 1–11 of 11 results
Advanced filters: Author: Fleur M. Ferguson Clear advanced filters

  • As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?” — here is what they said.

    • Lona M. Alkhalaf
    • Cheryl Arrowsmith
    • Georg Winter
    Special Features
    Nature Chemical Biology
    Volume: 21, P: 6-15

  • Unbiased chemical biology strategies for direct readout of small molecule protein interactomes provide advantages over target-focused approaches. Here, the authors describe the BioTAC system, a network-scale small molecule guided proximity labeling platform, to rapidly identify ligand-target interactomes.

    • Andrew J. Tao
    • Jiewei Jiang
    • Fleur M. Ferguson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • A highly selective inhibitor of the DCLK1/2 kinases is used to uncover the consequences of DCLK1 inhibition on viability, phosphosignaling and the transcriptome in patient-derived organoid models of pancreatic ductal adenocarcinoma.

    • Fleur M. Ferguson
    • Behnam Nabet
    • Nathanael S. Gray
    Research
    Nature Chemical Biology
    Volume: 16, P: 635-643

  • The dTAG system is used to rapidly deplete tagged target proteins in vitro and in vivo, but there are context- and protein-specific differences in its effectiveness. Here, the authors develop a second generation dTAG molecule that can degrade previously recalcitrant target proteins in cells and mice.

    • Behnam Nabet
    • Fleur M. Ferguson
    • Nathanael S. Gray
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Two recent studies identify derivatives of (+)-JQ1, a non-degrading inhibitor of BET bromodomains, as molecular glues that recruit DCAF16 and DCAF11 via mechanisms involving stabilization of transient target–ligase interactions.

    • YiYu Wang
    • M. S. S. Vinod Mouli
    • Fleur M. Ferguson
    News & Views
    Nature Chemical Biology
    Volume: 20, P: 1557-1558

  • A phase 1 trial of an IRAK4-targeted protein degrader in patients with chronic inflammatory skin diseases hits an important milestone for the safe application of this drug class beyond oncology.

    • Fleur M. Ferguson
    News & Views
    Nature Medicine
    Volume: 29, P: 3006-3007

  • Analysis with alleles encoding pharmacologically degradable Mediator subunits shows that Mediator acts as a global coactivator that facilitates transcription globally but is acutely required for cell-type-specific gene regulatory circuits.

    • Martin G. Jaeger
    • Björn Schwalb
    • Georg E. Winter
    Research
    Nature Genetics
    Volume: 52, P: 719-727

  • Existing kinase inhibitor drugs predominantly target receptor tyrosine kinases in cancer. Here, Gray and Ferguson review novel kinase targets in oncology, degenerative diseases, inflammatory disorders and infectious diseases. Advances in medicinal chemistry, selectivity profiling and computer-aided drug design, which are enabling the design of improved kinase inhibitors, are discussed.

    • Fleur M. Ferguson
    • Nathanael S. Gray
    Reviews
    Nature Reviews Drug Discovery
    Volume: 17, P: 353-377

  • Controlling kinase inhibitors’ residence time via reversible covalent binding is of high interest in drug discovery. Tuning reversible covalent binding kinetics using a pan-kinase inhibitor that reacts with the catalytic lysine enabled exquisite temporal selectivity in vitro and in vivo.

    • Fleur M. Ferguson
    News & Views
    Nature Chemical Biology
    Volume: 18, P: 917-918