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Showing 1–2 of 2 results
Advanced filters: Author: Florens Fischer Clear advanced filters

  • PTEN, a known tumour suppressor, inhibits the FXBL2-dependent degradation of IP3R3, an IP3 receptor, thus augmenting IP3R3-mediated calcium release from the endoplasmic reticulum to mitochondria and inducing apoptosis; inhibiting FXBL2 sensitizes PTEN-deficient tumours to photodynamic therapy.

    • Shafi Kuchay
    • Carlotta Giorgi
    • Michele Pagano
    Research
    Nature
    Volume: 546, P: 554-558

  • Structural biology plays a crucial role in the fight against COVID-19, permitting us to ‘see’ and understand SARS-CoV-2. However, the macromolecular structures of SARS-CoV-2 proteins that were solved with great speed and urgency can contain errors that may hinder drug design. The Coronavirus Structural Task Force has been working behind the scenes to evaluate and improve these structures, making the results freely available at https://insidecorona.net/.

    • Tristan I. Croll
    • Kay Diederichs
    • Andrea Thorn
    Comments & Opinion
    Nature Structural & Molecular Biology
    Volume: 28, P: 404-408